Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.G837D

c.2510G>A

Surrounding Variants

2 papers

NM_006218.4

p.G837V

c.2510G>T

1 paper

NM_006218.4

p.G837S

c.2509G>A

1 paper

NM_006218.4

p.G837C

c.2509G>T

1 paper

NM_006218.4

p.Y836C

c.2507A>G

2 papers

NM_006218.4

p.Y836F

c.2507A>T

1 paper

NM_006218.4

p.C838F

c.2513G>T

1 paper

NM_006218.4

p.C838W

c.2514T>G

1 paper

NM_006218.4

p.Y836fs

c.2506_2507fs

1 paper

NM_006218.4

p.Y836delFs

c.2507delA

1 paper

NM_006218.4

p.L839M

c.2515C>A

1 paper

NM_006218.4

p.P835L

c.2504C>T

1 paper

NM_006218.4

p.L839Q

c.2516T>A