Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.A893V

c.2678C>T

Surrounding Variants

1 paper

NM_006218.4

p.I894delFs

c.2680_2681delAT

1 paper

NM_006218.4

p.A893T

c.2677G>A

1 paper

NM_006218.4

p.A893S

c.2677G>T

1 paper

NM_006218.4

p.I894delFs

c.2681_2682delTT

1 paper

NM_006218.4

p.A892V

c.2675C>T

1 paper

NM_006218.4

p.A892T

c.2674G>A

1 paper

NM_006218.4

p.D895_L896del2

c.2683_2687del6

1 paper

NM_006218.4

p.D895H

c.2683G>C

3 papers

NM_006218.4

p.D891H

c.2671G>C

1 paper

NM_006218.4

p.L896M

c.2686C>A

1 paper

NM_006218.4

p.L896fs

c.2686_2687fs

1 paper

NM_006218.4

p.Y890C

c.2669A>G