Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_006218.4

p.G903R

c.2707G>C

Surrounding Variants

3 papers

NM_006218.4

p.G903R

c.2707G>A

1 paper

NM_006218.4

p.G903_Y904insA

c.2707_2711ins3

3 papers

NM_006218.4

p.G903E

c.2708G>A

1 paper

NM_006218.4

p.G903_Y904delFs

c.2707_2710del4

1 paper

NM_006218.4

p.A902T

c.2704G>A

1 paper

NM_006218.4

p.A902S

c.2704G>T

2 papers

NM_006218.4

p.Y904C

c.2711A>G

1 paper

NM_006218.4

p.A902_L911del10

c.2704_2732del30

2 papers

NM_006218.4

p.Y904*

c.2712C>G

4 papers

NM_006218.4

p.C901Y

c.2702G>A

65 papers

NM_006218.4

p.C901F

c.2702G>T

2 papers

NM_006218.4

p.C905S

c.2713T>A