Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.F909fs

c.2725_2726fs

Surrounding Variants

22 papers

NM_006218.4

p.F909L

c.2725T>C

1 paper

NM_006218.4

p.F909delFs

c.2726delT

2 papers

NM_006218.4

p.F909S

c.2726T>C

3 papers

NM_006218.4

p.F909C

c.2726T>G

21 papers

NM_006218.4

p.F909L

c.2727C>A

22 papers

NM_006218.4

p.F909L

c.2727C>G

1 paper

NM_006218.4

p.L911delFs

c.2732_2733delTG

2 papers

NM_006218.4

p.L911F

c.2733G>C

2 papers

NM_006218.4

p.L911F

c.2733G>T

3 papers

NM_006218.4

p.V906I

c.2716G>A

1 paper

NM_006218.4

p.G912R

c.2734G>A

1 paper

NM_006218.4

p.G912R

c.2734G>C