Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_006218.4

p.D926N

c.2776G>A

Surrounding Variants

1 paper

NM_006218.4

p.D925D

c.2775C>T

1 paper

NM_006218.4

p.G927R

c.2779G>A

1 paper

NM_006218.4

p.Q928R

c.2783A>G

1 paper

NM_006218.4

p.V923M

c.2767G>A

1 paper

NM_006218.4

p.V923L

c.2767G>C

1 paper

NM_006218.4

p.V923L

c.2767G>T

1 paper

NM_006218.4

p.M922L

c.2764A>C

1 paper

NM_006218.4

p.M922L

c.2764A>T

1 paper

NM_006218.4

p.I921L

c.2761A>C

1 paper

NM_006218.4

p.N920delFs

c.2760delC

1 paper

NM_006218.4

p.S919N

c.2756G>A

1 paper

NM_006218.4

p.N918K

c.2754T>A