Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.Q969insFs

c.2906_2907insC

Surrounding Variants

1 paper

NM_006218.4

p.Q969R

c.2906A>G

1 paper

NM_006218.4

p.Q969L

c.2906A>T

1 paper

NM_006218.4

p.Q969K

c.2905C>A

1 paper

NM_006218.4

p.Q969_E970insG

c.2905_2909ins3

1 paper

NM_006218.4

p.Q969fs

c.2905_2906fs

49 papers

NM_006218.4

p.E970K

c.2908G>A

1 paper

NM_006218.4

p.E970Q

c.2908G>C

1 paper

NM_006218.4

p.E970A

c.2909A>C

1 paper

NM_006218.4

p.E970G

c.2909A>G

1 paper

NM_006218.4

p.A968_Q969insA

c.2902_2906ins3

2 papers

NM_006218.4

p.C971S

c.2911T>A

5 papers

NM_006218.4

p.C971R

c.2911T>C