Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.F977Y

c.2930T>A

Surrounding Variants

1 paper

NM_006218.4

p.F977L

c.2931T>A

1 paper

NM_006218.4

p.F977L

c.2929T>C

1 paper

NM_006218.4

p.F977L

c.2931T>G

2 papers

NM_006218.4

p.F977_E978insC

c.2929_2933ins3

1 paper

NM_006218.4

p.F977insFs

c.2929dupT

1 paper

NM_006218.4

p.E976D

c.2928A>C

1 paper

NM_006218.4

p.E976D

c.2928A>T

1 paper

NM_006218.4

p.E978K

c.2932G>A

2 papers

NM_006218.4

p.E978Q

c.2932G>C

2 papers

NM_006218.4

p.E978*

c.2932G>T

1 paper

NM_006218.4

p.E978G

c.2933A>G

1 paper

NM_006218.4

p.E978V

c.2933A>T