Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

61 papers

NM_006218.4

p.M1004I

c.3012G>C

Surrounding Variants

63 papers

NM_006218.4

p.M1004I

c.3012G>A

65 papers

NM_006218.4

p.M1004I

c.3012G>T

3 papers

NM_006218.4

p.M1005V

c.3013A>G

2 papers

NM_006218.4

p.M1004R

c.3011T>G

16 papers

NM_006218.4

p.M1004V

c.3010A>G

3 papers

NM_006218.4

p.M1005I

c.3015G>A

3 papers

NM_006218.4

p.M1005I

c.3015G>C

3 papers

NM_006218.4

p.M1005I

c.3015G>T

2 papers

NM_006218.4

p.L1006I

c.3016C>A

1 paper

NM_006218.4

p.S1003*

c.3008C>A

1 paper

NM_006218.4

p.S1003*

c.3008C>G

5 papers

NM_006218.4

p.L1006F

c.3016C>T