Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_006218.4

p.E1012Q

c.3034G>C

Surrounding Variants

6 papers

NM_006218.4

p.E1012K

c.3034G>A

2 papers

NM_006218.4

p.E1012_L1013insT

c.3034_3038ins3

1 paper

NM_006218.4

p.E1012*

c.3034G>T

2 papers

NM_006218.4

p.P1011P

c.3033A>G

2 papers

NM_006218.4

p.E1012G

c.3035A>G

2 papers

NM_006218.4

p.E1012D

c.3036A>C

2 papers

NM_006218.4

p.E1012D

c.3036A>T

1 paper

NM_006218.4

p.P1011Q

c.3032C>A

5 papers

NM_006218.4

p.P1011L

c.3032C>T

1 paper

NM_006218.4

p.P1011T

c.3031C>A

1 paper

NM_006218.4

p.L1013I

c.3037C>A

7 papers

NM_006218.4

p.P1011S

c.3031C>T