Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.S1015C

c.3044C>G

Surrounding Variants

3 papers

NM_006218.4

p.S1015Y

c.3044C>A

6 papers

NM_006218.4

p.S1015F

c.3044C>T

1 paper

NM_006218.4

p.S1015P

c.3043T>C

2 papers

NM_006218.4

p.S1015A

c.3043T>G

2 papers

NM_006218.4

p.Q1014Q

c.3042A>G

2 papers

NM_006218.4

p.F1016L

c.3046T>C

3 papers

NM_006218.4

p.Q1014R

c.3041A>G

1 paper

NM_006218.4

p.F1016Y

c.3047T>A

2 papers

NM_006218.4

p.F1016C

c.3047T>G

2 papers

NM_006218.4

p.Q1014K

c.3040C>A

3 papers

NM_006218.4

p.Q1014*

c.3040C>T

1 paper

NM_006218.4

p.F1016L

c.3048T>A