Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.D1018G

c.3053A>G

Surrounding Variants

4 papers

NM_006218.4

p.D1018V

c.3053A>T

7 papers

NM_006218.4

p.D1018N

c.3052G>A

1 paper

NM_006218.4

p.D1018H

c.3052G>C

4 papers

NM_006218.4

p.I1019V

c.3055A>G

2 papers

NM_006218.4

p.I1019F

c.3055A>T

2 papers

NM_006218.4

p.D1017E

c.3051T>A

2 papers

NM_006218.4

p.D1017E

c.3051T>G

3 papers

NM_006218.4

p.D1017G

c.3050A>G

4 papers

NM_006218.4

p.D1017V

c.3050A>T

1 paper

NM_006218.4

p.I1019T

c.3056T>C

3 papers

NM_006218.4

p.D1017N

c.3049G>A

22 papers

NM_006218.4

p.D1017H

c.3049G>C