Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

45 papers

NM_006218.4

p.Y1021H

c.3061T>C

Surrounding Variants

8 papers

NM_006218.4

p.Y1021N

c.3061T>A

4 papers

NM_006218.4

p.Y1021S

c.3062A>C

154 papers

NM_006218.4

p.Y1021C

c.3062A>G

1 paper

NM_006218.4

p.A1020A

c.3060A>G

3 papers

NM_006218.4

p.Y1021F

c.3062A>T

1 paper

NM_006218.4

p.A1020E

c.3059C>A

1 paper

NM_006218.4

p.Y1021*

c.3063C>A

1 paper

NM_006218.4

p.Y1021*

c.3063C>G

15 papers

NM_006218.4

p.A1020V

c.3059C>T

1 paper

NM_006218.4

p.Y1021Y

c.3063C>T

2 papers

NM_006218.4

p.I1022_R1023insT

c.3064_3068ins3

1 paper

NM_006218.4

p.I1022V

c.3064A>G