Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_006218.4

p.K1030E

c.3088A>G

Surrounding Variants

2 papers

NM_006218.4

p.K1030R

c.3089A>G

2 papers

NM_006218.4

p.D1029E

c.3087T>A

3 papers

NM_006218.4

p.D1029E

c.3087T>G

1 paper

NM_006218.4

p.D1029A

c.3086A>C

3 papers

NM_006218.4

p.D1029G

c.3086A>G

1 paper

NM_006218.4

p.D1029V

c.3086A>T

2 papers

NM_006218.4

p.T1031A

c.3091A>G

8 papers

NM_006218.4

p.D1029N

c.3085G>A

15 papers

NM_006218.4

p.D1029H

c.3085G>C

5 papers

NM_006218.4

p.D1029Y

c.3085G>T

1 paper

NM_006218.4

p.D1029_K1030delFs

c.3087_3088delTA

6 papers

NM_006218.4

p.T1031I

c.3092C>T