Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.L1036F

c.3108G>T

Surrounding Variants

2 papers

NM_006218.4

p.L1036F

c.3108G>C

8 papers

NM_006218.4

p.E1037K

c.3109G>A

2 papers

NM_006218.4

p.E1037Q

c.3109G>C

1 paper

NM_006218.4

p.E1037*

c.3109G>T

1 paper

NM_006218.4

p.L1036S

c.3107T>C

5 papers

NM_006218.4

p.E1037G

c.3110A>G

1 paper

NM_006218.4

p.E1037V

c.3110A>T

1 paper

NM_006218.4

p.E1037E

c.3111G>A

1 paper

NM_006218.4

p.E1037D

c.3111G>C

1 paper

NM_006218.4

p.E1037D

c.3111G>T

1 paper

NM_006218.4

p.A1035A

c.3105T>G

44 papers

NM_006218.4

p.A1035V

c.3104C>T