Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.T1052T

c.3156A>T

Surrounding Variants

1 paper

NM_006218.4

p.T1053_K1054ins9

c.3157_3161ins27

7 papers

NM_006218.4

p.T1053A

c.3157A>G

27 papers

NM_006218.4

p.T1052K

c.3155C>A

6 papers

NM_006218.4

p.T1052I

c.3155C>T

3 papers

NM_006218.4

p.T1052A

c.3154A>G

2 papers

NM_006218.4

p.T1052S

c.3154A>T

1 paper

NM_006218.4

p.T1053K

c.3158C>A

2 papers

NM_006218.4

p.T1053I

c.3158C>T

6 papers

NM_006218.4

p.W1051*

c.3153G>A

6 papers

NM_006218.4

p.W1051*

c.3152G>A

3 papers

NM_006218.4

p.W1051R

c.3151T>A

3 papers

NM_006218.4

p.W1051R

c.3151T>C