Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.K1063insFs

c.3189dupA

Surrounding Variants

1 paper

NM_006218.4

p.I1062T

c.3185T>C

3 papers

NM_006218.4

p.I1062V

c.3184A>G

1 paper

NM_006218.4

p.I1062F

c.3184A>T

1 paper

NM_006218.4

p.T1061K

c.3182C>A

2 papers

NM_006218.4

p.Q1064insFs

c.3190_3191insA

1 paper

NM_006218.4

p.Q1064fs

c.3190_3191fs

2 papers

NM_006218.4

p.T1061R

c.3182C>G

1 paper

NM_006218.4

p.T1061I

c.3182C>T

1 paper

NM_006218.4

p.Q1064*

c.3190C>T

1 paper

NM_006218.4

p.Q1064Fs

c.3190_3191delinsTFs

2 papers

NM_006218.4

p.T1061A

c.3181A>G

2 papers

NM_006218.4

p.Q1064R

c.3191A>G