Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_006218.4

p.N1068insFs

c.3203dupA

Surrounding Variants

1 paper

NM_006218.4

p.L1067L

c.3201G>A

5 papers

NM_006218.4

p.L1067F

c.3201G>C

5 papers

NM_006218.4

p.L1067F

c.3201G>T

36 papers

NM_006218.4

p.N1068fs

c.3202_3203fs

1 paper

NM_006218.4

p.N1068D

c.3202A>G

4 papers

NM_006218.4

p.N1068fs

c.3202_3203fs

1 paper

NM_006218.4

p.N1068insFs

c.3204dupC

1 paper

NM_006218.4

p.N1068T

c.3203A>C

4 papers

NM_006218.4

p.N1068S

c.3203A>G

3 papers

NM_006218.4

p.L1067fs

c.3199_3200fs

5 papers

NM_006218.4

p.N1068K

c.3204C>A

20 papers

NM_006218.4

p.N1068_*1069insFs

c.3204_3205insA