Varaico: Literature-Extracted Genetic Variants

PIK3CG

507 papers

RefSeq Summary

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I ca...

Pfam Domains

PIK3CG_ABDaa 1–192UCSCPIK3 catalytic subunit gamma adaptor-binding domain

PI3K_rbdaa 203–312UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 377–519UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 543–733UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 827–1044UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

HGNC Previous Names

phosphoinositide-3-kinase, catalytic, gamma polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_001282426.2

p.P208L

c.623C>T

Surrounding Variants

1 paper

NM_001282426.2

p.P208P

c.624G>A

1 paper

NM_001282426.2

p.L211M

c.631C>A

1 paper

NM_001282426.2

p.K205N

c.615G>C

1 paper

NM_001282426.2

p.K205N

c.615G>T

1 paper

NM_001282426.2

p.P206delFs

c.616_617delCC

2 papers

NM_001282426.2

p.W212*

c.635G>A

2 papers

NM_001282426.2

p.W212*

c.636G>A

1 paper

NM_001282426.2

p.K213_K214insT

c.637_641ins3

1 paper

NM_001282426.2

p.T203T

c.609G>T

5 papers

NM_001282426.2

p.T203M

c.608C>T

1 paper

NM_001282426.2

p.W201S

c.602G>C

1 paper

NM_001282426.2

p.W201G

c.601T>G