Varaico: Literature-Extracted Genetic Variants

PIK3CG

507 papers

RefSeq Summary

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I ca...

Pfam Domains

PIK3CG_ABDaa 1–192UCSCPIK3 catalytic subunit gamma adaptor-binding domain

PI3K_rbdaa 203–312UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 377–519UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 543–733UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 827–1044UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

HGNC Previous Names

phosphoinositide-3-kinase, catalytic, gamma polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_001282426.2

p.D358Y

c.1072G>T

Surrounding Variants

2 papers

NM_001282426.2

p.R359S

c.1075C>A

5 papers

NM_001282426.2

p.R359H

c.1076G>A

1 paper

NM_001282426.2

p.W355R

c.1063T>A

1 paper

NM_001282426.2

p.W355R

c.1063T>C

1 paper

NM_001282426.2

p.K364R

c.1091A>G

1 paper

NM_001282426.2

p.I365M

c.1095C>G

1 paper

NM_001282426.2

p.R366G

c.1096A>G

1 paper

NM_001282426.2

p.V349G

c.1046T>G

1 paper

NM_001282426.2

p.I368V

c.1102A>G

5 papers

NM_001282426.2

p.E347K

c.1039G>A

1 paper

NM_001282426.2

p.D369A

c.1106A>C

1 paper

NM_001282426.2

p.P371T

c.1111C>A