Varaico: Literature-Extracted Genetic Variants

PIK3CG

507 papers

RefSeq Summary

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I ca...

Pfam Domains

PIK3CG_ABDaa 1–192UCSCPIK3 catalytic subunit gamma adaptor-binding domain

PI3K_rbdaa 203–312UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 377–519UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 543–733UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 827–1044UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

HGNC Previous Names

phosphoinositide-3-kinase, catalytic, gamma polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001282426.2

p.P866S

c.2596C>T

Surrounding Variants

1 paper

NM_001282426.2

p.Y867C

c.2600A>G

1 paper

NM_001282426.2

p.Y867F

c.2600A>T

1 paper

NM_001282426.2

p.L862P

c.2585T>C

1 paper

NM_001282426.2

p.I870V

c.2608A>G

1 paper

NM_001282426.2

p.G873V

c.2618G>T

1 paper

NM_001282426.2

p.E858K

c.2572G>A

1 paper

NM_001282426.2

p.K875fs

c.2623_2624fs

9 papers

NM_001282426.2

p.T857A

c.2569A>G

2 papers

NM_001282426.2

p.K875R

c.2624A>G

1 paper

NM_001282426.2

p.G877Splc

c.2629+1G>T

1 paper

NM_001282426.2

p.I854T

c.2561T>C

1 paper

NM_001282426.2

p.S853C

c.2558C>G