Varaico: Literature-Extracted Genetic Variants

PIK3R2

732 papers

RefSeq Summary

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions...

Pfam Domains

RhoGAPaa 125–259UCSCRhoGAP domain

SH2aa 330–405UCSCSH2 domain

PI3K_P85_iSH2aa 428–596UCSCPhosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SH2aa 622–696UCSCSH2 domain

Gene Aliases

HGNC Name

phosphoinositide-3-kinase regulatory subunit 2

HGNC Alias Symbols

P85B; p85; p85beta; p85-BETA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005027.4

p.Q39*

c.115C>T

Surrounding Variants

1 paper

NM_005027.4

p.L41M

c.121C>A

1 paper

NM_005027.4

p.A37insFs

c.110_111ins8

1 paper

NM_005027.4

p.A37_P51del15

c.109_152del45

1 paper

NM_005027.4

p.A36G

c.107C>G

1 paper

NM_005027.4

p.A36T

c.106G>A

2 papers

NM_005027.4

p.R35Q

c.104G>A

2 papers

NM_005027.4

p.R35W

c.103C>T

1 paper

NM_005027.4

p.S34N

c.101G>A

1 paper

NM_005027.4

p.A44T

c.130G>A

1 paper

NM_005027.4

p.V33V

c.99G>A

1 paper

NM_005027.4

p.V33G

c.98T>G

1 paper

NM_005027.4

p.G46G

c.138T>A