Varaico: Literature-Extracted Genetic Variants

PIK3R2

732 papers

RefSeq Summary

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions...

Pfam Domains

RhoGAPaa 125–259UCSCRhoGAP domain

SH2aa 330–405UCSCSH2 domain

PI3K_P85_iSH2aa 428–596UCSCPhosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SH2aa 622–696UCSCSH2 domain

Gene Aliases

HGNC Name

phosphoinositide-3-kinase regulatory subunit 2

HGNC Alias Symbols

P85B; p85; p85beta; p85-BETA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005027.4

p.S53_P58del0

c.159_173del15

Surrounding Variants

1 paper

NM_005027.4

p.S53R

c.157A>C

1 paper

NM_005027.4

p.S53R

c.159C>A

1 paper

NM_005027.4

p.S53R

c.159C>G

10 papers

NM_005027.4

p.V54M

c.160G>A

2 papers

NM_005027.4

p.Q52H

c.156G>C

2 papers

NM_005027.4

p.Q52H

c.156G>T

1 paper

NM_005027.4

p.W56R

c.166T>A

1 paper

NM_005027.4

p.W56R

c.166T>C

1 paper

NM_005027.4

p.M57V

c.169A>G

1 paper

NM_005027.4

p.M57_E62del0

c.170_184del15

1 paper

NM_005027.4

p.P58_E62del0

c.172_186del15

1 paper

NM_005027.4

p.G47G

c.141C>T