Varaico: Literature-Extracted Genetic Variants

PIK3R2

732 papers

RefSeq Summary

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions...

Pfam Domains

RhoGAPaa 125–259UCSCRhoGAP domain

SH2aa 330–405UCSCSH2 domain

PI3K_P85_iSH2aa 428–596UCSCPhosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SH2aa 622–696UCSCSH2 domain

Gene Aliases

HGNC Name

phosphoinositide-3-kinase regulatory subunit 2

HGNC Alias Symbols

P85B; p85; p85beta; p85-BETA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_005027.4

p.R89C

c.265C>T

Surrounding Variants

1 paper

NM_005027.4

p.P88P

c.264T>C

1 paper

NM_005027.4

p.P90A

c.268C>G

1 paper

NM_005027.4

p.G87G

c.261C>A

1 paper

NM_005027.4

p.G87fs

c.259_260fs

1 paper

NM_005027.4

p.P86P

c.258C>A

1 paper

NM_005027.4

p.R91Q

c.272G>A

1 paper

NM_005027.4

p.R85L

c.254G>T

1 paper

NM_005027.4

p.P93A

c.277C>G

1 paper

NM_005027.4

p.R85W

c.253C>T

1 paper

NM_005027.4

p.A84T

c.250G>A

1 paper

NM_005027.4

p.A84fs

c.250_251fs

2 papers

NM_005027.4

p.R94H

c.281G>A