Varaico: Literature-Extracted Genetic Variants

PIK3R2

732 papers

RefSeq Summary

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions...

Pfam Domains

RhoGAPaa 125–259UCSCRhoGAP domain

SH2aa 330–405UCSCSH2 domain

PI3K_P85_iSH2aa 428–596UCSCPhosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SH2aa 622–696UCSCSH2 domain

Gene Aliases

HGNC Name

phosphoinositide-3-kinase regulatory subunit 2

HGNC Alias Symbols

P85B; p85; p85beta; p85-BETA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005027.4

p.P97A

c.289C>G

Surrounding Variants

1 paper

NM_005027.4

p.P97L

c.290C>T

1 paper

NM_005027.4

p.A98T

c.292G>A

1 paper

NM_005027.4

p.R99K

c.296G>A

2 papers

NM_005027.4

p.R94H

c.281G>A

1 paper

NM_005027.4

p.P93A

c.277C>G

1 paper

NM_005027.4

p.R101C

c.301C>T

2 papers

NM_005027.4

p.R101H

c.302G>A

1 paper

NM_005027.4

p.R91Q

c.272G>A

1 paper

NM_005027.4

p.G103R

c.307G>A

1 paper

NM_005027.4

p.G103R

c.307G>C

1 paper

NM_005027.4

p.G103E

c.308G>A

1 paper

NM_005027.4

p.G103V

c.308G>T