Varaico: Literature-Extracted Genetic Variants

PIK3R2

732 papers

RefSeq Summary

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions...

Pfam Domains

RhoGAPaa 125–259UCSCRhoGAP domain

SH2aa 330–405UCSCSH2 domain

PI3K_P85_iSH2aa 428–596UCSCPhosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SH2aa 622–696UCSCSH2 domain

Gene Aliases

HGNC Name

phosphoinositide-3-kinase regulatory subunit 2

HGNC Alias Symbols

P85B; p85; p85beta; p85-BETA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005027.4

p.W330G

c.988T>G

Surrounding Variants

1 paper

NM_005027.4

p.W330R

c.988T>A

1 paper

NM_005027.4

p.W330R

c.988T>C

1 paper

NM_005027.4

p.A328D

c.983C>A

1 paper

NM_005027.4

p.A328_W330del3

c.982_989del9

1 paper

NM_005027.4

p.D334G

c.1001A>G

1 paper

NM_005027.4

p.I335Fs

c.1003delinsGAFs

1 paper

NM_005027.4

p.R337G

c.1009A>G

1 paper

NM_005027.4

p.R337W

c.1009A>T

1 paper

NM_005027.4

p.P322Q

c.965C>A

1 paper

NM_005027.4

p.P322L

c.965C>T

1 paper

NM_005027.4

p.R337Splc

c.1010+3A>T

1 paper

NM_005027.4

p.S321N

c.962G>A