Varaico: Literature-Extracted Genetic Variants

PIK3R2

732 papers

RefSeq Summary

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions...

Pfam Domains

RhoGAPaa 125–259UCSCRhoGAP domain

SH2aa 330–405UCSCSH2 domain

PI3K_P85_iSH2aa 428–596UCSCPhosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SH2aa 622–696UCSCSH2 domain

Gene Aliases

HGNC Name

phosphoinositide-3-kinase regulatory subunit 2

HGNC Alias Symbols

P85B; p85; p85beta; p85-BETA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005027.4

p.V380D

c.1139T>A

Surrounding Variants

2 papers

NM_005027.4

p.K379N

c.1137G>C

2 papers

NM_005027.4

p.K379N

c.1137G>T

1 paper

NM_005027.4

p.F381L

c.1141T>C

6 papers

NM_005027.4

p.K379E

c.1135A>G

1 paper

NM_005027.4

p.F381L

c.1143C>A

1 paper

NM_005027.4

p.F381L

c.1143C>G

1 paper

NM_005027.4

p.K376K

c.1128G>A

1 paper

NM_005027.4

p.D384N

c.1150G>A

1 paper

NM_005027.4

p.K376N

c.1128G>C

1 paper

NM_005027.4

p.K376N

c.1128G>T

12 papers

NM_005027.4

p.K376E

c.1126A>G

2 papers

NM_005027.4

p.G385R

c.1153G>A