Varaico: Literature-Extracted Genetic Variants

PIK3R2

732 papers

RefSeq Summary

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions...

Pfam Domains

RhoGAPaa 125–259UCSCRhoGAP domain

SH2aa 330–405UCSCSH2 domain

PI3K_P85_iSH2aa 428–596UCSCPhosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SH2aa 622–696UCSCSH2 domain

Gene Aliases

HGNC Name

phosphoinositide-3-kinase regulatory subunit 2

HGNC Alias Symbols

P85B; p85; p85beta; p85-BETA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005027.4

p.K564Q

c.1690A>C

Surrounding Variants

11 papers

NM_005027.4

p.K564E

c.1690A>G

1 paper

NM_005027.4

p.P565R

c.1694C>G

1 paper

NM_005027.4

p.P565P

c.1695G>A

2 papers

NM_005027.4

p.S562I

c.1685G>T

1 paper

NM_005027.4

p.D566Y

c.1696G>T

1 paper

NM_005027.4

p.D566delins

c.1696_1697delinsTT

1 paper

NM_005027.4

p.N561T

c.1682A>C

11 papers

NM_005027.4

p.N561D

c.1681A>G

1 paper

NM_005027.4

p.M560T

c.1679T>C

1 paper

NM_005027.4

p.M568L

c.1702A>C

1 paper

NM_005027.4

p.M568V

c.1702A>G

1 paper

NM_005027.4

p.M568L

c.1702A>T