Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.T6T

c.18T>A

Surrounding Variants

1 paper

NM_005030.6

p.G8E

c.23G>A

1 paper

NM_005030.6

p.K9*

c.25A>T

1 paper

NM_005030.6

p.A11T

c.31G>A

1 paper

NM_005030.6

p.M1I

c.3G>A

1 paper

NM_005030.6

p.M1delins

c.3delinsTTTTAGATCCATATTTTAG

1 paper

NM_005030.6

p.M1Fs

c.1delinsTTFs

1 paper

NM_005030.6

p.R12L

c.35G>T

1 paper

NM_005030.6

p.D16G

c.47A>G

1 paper

NM_005030.6

p.P17H

c.50C>A

1 paper

NM_005030.6

p.P17L

c.50C>T

1 paper

NM_005030.6

p.K19R

c.56A>G

1 paper

NM_005030.6

p.A20A

c.60C>T