Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005030.6

p.V43A

c.128T>C

Surrounding Variants

1 paper

NM_005030.6

p.E42*

c.124G>T

1 paper

NM_005030.6

p.V45L

c.133G>C

1 paper

NM_005030.6

p.V45L

c.133G>T

1 paper

NM_005030.6

p.P41Q

c.122C>A

1 paper

NM_005030.6

p.D46N

c.136G>A

1 paper

NM_005030.6

p.I40N

c.119T>A

1 paper

NM_005030.6

p.E39D

c.117G>T

1 paper

NM_005030.6

p.E39Q

c.115G>C

1 paper

NM_005030.6

p.R48fs

c.142_143fs

1 paper

NM_005030.6

p.R48H

c.143G>A

1 paper

NM_005030.6

p.R48delFs

c.144delC

1 paper

NM_005030.6

p.S49N

c.146G>A