Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.L59F

c.177G>C

Surrounding Variants

1 paper

NM_005030.6

p.L59F

c.177G>T

1 paper

NM_005030.6

p.L59W

c.176T>G

2 papers

NM_005030.6

p.L59fs

c.175_176fs

1 paper

NM_005030.6

p.F58L

c.174T>A

1 paper

NM_005030.6

p.L59insFs

c.176dupT

1 paper

NM_005030.6

p.L59delFs

c.176delT

1 paper

NM_005030.6

p.R57H

c.170G>A

1 paper

NM_005030.6

p.R57S

c.169C>A

1 paper

NM_005030.6

p.G63S

c.187G>A

1 paper

NM_005030.6

p.A65T

c.193G>A

1 paper

NM_005030.6

p.A65S

c.193G>T

1 paper

NM_005030.6

p.Y53C

c.158A>G