Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.S71A

c.211T>G

Surrounding Variants

1 paper

NM_005030.6

p.I70N

c.209T>A

1 paper

NM_005030.6

p.E69_I70delins

c.207_208delinsTG

1 paper

NM_005030.6

p.E69*

c.205G>T

1 paper

NM_005030.6

p.F68L

c.204C>A

1 paper

NM_005030.6

p.F68L

c.204C>G

1 paper

NM_005030.6

p.D74N

c.220G>A

1 paper

NM_005030.6

p.F68L

c.202T>C

1 paper

NM_005030.6

p.K66R

c.197A>G

2 papers

NM_005030.6

p.E77K

c.229G>A

1 paper

NM_005030.6

p.A65T

c.193G>A

1 paper

NM_005030.6

p.A65S

c.193G>T

1 paper

NM_005030.6

p.G63S

c.187G>A