Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.H93R

c.278A>G

Surrounding Variants

1 paper

NM_005030.6

p.H93Y

c.277C>T

1 paper

NM_005030.6

p.Q94R

c.281A>G

1 paper

NM_005030.6

p.R95M

c.284G>T

1 paper

NM_005030.6

p.E96del1

c.286_288delGAG

1 paper

NM_005030.6

p.R95S

c.285G>C

1 paper

NM_005030.6

p.R95S

c.285G>T

1 paper

NM_005030.6

p.K97K

c.291G>A

1 paper

NM_005030.6

p.M98L

c.292A>T

1 paper

NM_005030.6

p.L88fs

c.262_263fs

2 papers

NM_005030.6

p.S99A

c.295T>G

1 paper

NM_005030.6

p.S99F

c.296C>T

1 paper

NM_005030.6

p.K86N

c.258G>C