Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.E121G

c.362A>G

Surrounding Variants

1 paper

NM_005030.6

p.D124N

c.370G>A

1 paper

NM_005030.6

p.F125L

c.373T>C

1 paper

NM_005030.6

p.F125L

c.375C>A

1 paper

NM_005030.6

p.F125L

c.375C>G

1 paper

NM_005030.6

p.H117Y

c.349C>T

1 paper

NM_005030.6

p.F116L

c.348C>A

1 paper

NM_005030.6

p.F116L

c.348C>G

1 paper

NM_005030.6

p.F116L

c.346T>C

1 paper

NM_005030.6

p.G115E

c.344G>A

1 paper

NM_005030.6

p.H112Y

c.334C>T

1 paper

NM_005030.6

p.E131*

c.391G>T

1 paper

NM_005030.6

p.H110R

c.329A>G