Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.V172I

c.514G>A

Surrounding Variants

1 paper

NM_005030.6

p.R171Q

c.512G>A

1 paper

NM_005030.6

p.I173V

c.517A>G

1 paper

NM_005030.6

p.R171*

c.511C>T

1 paper

NM_005030.6

p.H174Y

c.520C>T

1 paper

NM_005030.6

p.R169Q

c.506G>A

1 paper

NM_005030.6

p.R169ins8

c.506_507ins24

1 paper

NM_005030.6

p.R175G

c.523C>G

1 paper

NM_005030.6

p.R169*

c.505C>T

1 paper

NM_005030.6

p.R175*

c.523C>T

1 paper

NM_005030.6

p.R175Q

c.524G>A

1 paper

NM_005030.6

p.R175P

c.524G>C

3 papers

NM_005030.6

p.D176N

c.526G>A