Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.E186D

c.558A>T

Surrounding Variants

1 paper

NM_005030.6

p.E186D

c.558A>C

1 paper

NM_005030.6

p.E186*

c.556G>T

1 paper

NM_005030.6

p.L188P

c.563T>C

1 paper

NM_005030.6

p.E189G

c.566A>G

1 paper

NM_005030.6

p.V190M

c.568G>A

1 paper

NM_005030.6

p.K191R

c.572A>G

1 paper

NM_005030.6

p.G180D

c.539G>A

1 paper

NM_005030.6

p.K178R

c.533A>G

1 paper

NM_005030.6

p.D176G

c.527A>G

3 papers

NM_005030.6

p.D176N

c.526G>A

1 paper

NM_005030.6

p.R175Q

c.524G>A

1 paper

NM_005030.6

p.R175P

c.524G>C