Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.T199I

c.596C>T

Surrounding Variants

1 paper

NM_005030.6

p.T199T

c.597C>A

1 paper

NM_005030.6

p.K200E

c.598A>G

1 paper

NM_005030.6

p.K200R

c.599A>G

1 paper

NM_005030.6

p.V201I

c.601G>A

2 papers

NM_005030.6

p.E202K

c.604G>A

1 paper

NM_005030.6

p.G196E

c.587G>A

2 papers

NM_005030.6

p.G196V

c.587G>T

1 paper

NM_005030.6

p.Y203*

c.609T>A

5 papers

NM_005030.6

p.D194A

c.581A>C

1 paper

NM_005030.6

p.D204G

c.611A>G

1 paper

NM_005030.6

p.G193G

c.579G>A

1 paper

NM_005030.6

p.G205V

c.614G>T