Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.I218L

c.652A>C

Surrounding Variants

1 paper

NM_005030.6

p.I218L

c.652A>T

2 papers

NM_005030.6

p.Y217F

c.650A>T

1 paper

NM_005030.6

p.P220A

c.658C>G

1 paper

NM_005030.6

p.P220L

c.659C>T

1 paper

NM_005030.6

p.P220delins

c.659_660delinsTT

1 paper

NM_005030.6

p.E221*

c.661G>T

1 paper

NM_005030.6

p.V222L

c.664G>C

1 paper

NM_005030.6

p.V222L

c.664G>T

1 paper

NM_005030.6

p.G213V

c.638G>T

1 paper

NM_005030.6

p.L223R

c.668T>G

1 paper

NM_005030.6

p.S224R

c.670A>C

1 paper

NM_005030.6

p.S224R

c.672C>A