Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005030.6

p.I240I

c.720C>T

Surrounding Variants

1 paper

NM_005030.6

p.C239S

c.716G>C

1 paper

NM_005030.6

p.M241Splc

c.722+2T>C

1 paper

NM_005030.6

p.C239S

c.715T>A

1 paper

NM_005030.6

p.W235L

c.704G>T

1 paper

NM_005030.6

p.V234L

c.700G>C

1 paper

NM_005030.6

p.V234L

c.700G>T

1 paper

NM_005030.6

p.V234fs

c.700_701fs

1 paper

NM_005030.6

p.V234insFs

c.700dupG

1 paper

NM_005030.6

p.D233G

c.698A>G

1 paper

NM_005030.6

p.D233Y

c.697G>T

1 paper

NM_005030.6

p.M241Splc

c.722+26A>G

1 paper

NM_005030.6

p.E231K

c.691G>A