Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005030.6

p.W414*

c.1241G>A

Surrounding Variants

2 papers

NM_005030.6

p.W414*

c.1242G>A

4 papers

NM_005030.6

p.V415A

c.1244T>C

1 paper

NM_005030.6

p.K413_W414del2

c.1237_1241del6

1 paper

NM_005030.6

p.D416N

c.1246G>A

1 paper

NM_005030.6

p.D416Y

c.1246G>T

1 paper

NM_005030.6

p.S418A

c.1252T>G

2 papers

NM_005030.6

p.S418L

c.1253C>T

1 paper

NM_005030.6

p.D419N

c.1255G>A

1 paper

NM_005030.6

p.I408fs

c.1222_1223fs

1 paper

NM_005030.6

p.Y421N

c.1261T>A

1 paper

NM_005030.6

p.P407H

c.1220C>A

1 paper

NM_005030.6

p.P407L

c.1220C>T