Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005030.6

p.Y485H

c.1453T>C

Surrounding Variants

2 papers

NM_005030.6

p.M486I

c.1458G>A

1 paper

NM_005030.6

p.R483H

c.1448G>A

2 papers

NM_005030.6

p.M486I

c.1458G>C

2 papers

NM_005030.6

p.M486I

c.1458G>T

1 paper

NM_005030.6

p.S487R

c.1459A>C

1 paper

NM_005030.6

p.R483C

c.1447C>T

1 paper

NM_005030.6

p.F482F

c.1446C>T

1 paper

NM_005030.6

p.S487R

c.1461C>A

1 paper

NM_005030.6

p.S487R

c.1461C>G

1 paper

NM_005030.6

p.Y481D

c.1441T>G

1 paper

NM_005030.6

p.K480N

c.1440A>C

1 paper

NM_005030.6

p.K480N

c.1440A>T