Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.T513S

c.1537A>T

Surrounding Variants

1 paper

NM_005030.6

p.T513S

c.1538C>G

1 paper

NM_005030.6

p.T513I

c.1538C>T

1 paper

NM_005030.6

p.R512Q

c.1535G>A

1 paper

NM_005030.6

p.L511I

c.1531C>A

1 paper

NM_005030.6

p.F515L

c.1543T>C

1 paper

NM_005030.6

p.Y510C

c.1529A>G

1 paper

NM_005030.6

p.F515L

c.1545C>A

1 paper

NM_005030.6

p.F515L

c.1545C>G

1 paper

NM_005030.6

p.R516C

c.1546C>T

1 paper

NM_005030.6

p.R516H

c.1547G>A

1 paper

NM_005030.6

p.P509S

c.1525C>T

1 paper

NM_005030.6

p.T517I

c.1550C>T