Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.K556N

c.1668G>T

Surrounding Variants

1 paper

NM_005030.6

p.K556N

c.1668G>C

2 papers

NM_005030.6

p.R557W

c.1669C>T

1 paper

NM_005030.6

p.R557Q

c.1670G>A

1 paper

NM_005030.6

p.D554H

c.1660G>C

1 paper

NM_005030.6

p.R560delFs

c.1678delC

1 paper

NM_005030.6

p.R560C

c.1678C>T

1 paper

NM_005030.6

p.R560fs

c.1678_1679fs

1 paper

NM_005030.6

p.R560H

c.1679G>A

1 paper

NM_005030.6

p.Y562C

c.1685A>G

1 paper

NM_005030.6

p.R563C

c.1687C>T

3 papers

NM_005030.6

p.V550M

c.1648G>A

1 paper

NM_005030.6

p.R563H

c.1688G>A