Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.S565fs

c.1693_1694fs

Surrounding Variants

1 paper

NM_005030.6

p.S565insFs

c.1693dupA

1 paper

NM_005030.6

p.L566V

c.1696C>G

1 paper

NM_005030.6

p.R563H

c.1688G>A

1 paper

NM_005030.6

p.R563C

c.1687C>T

1 paper

NM_005030.6

p.E569del1

c.1705_1706delGAG

1 paper

NM_005030.6

p.Y562C

c.1685A>G

1 paper

NM_005030.6

p.E568*

c.1702G>T

1 paper

NM_005030.6

p.E568A

c.1703A>C

1 paper

NM_005030.6

p.E568D

c.1704G>C

1 paper

NM_005030.6

p.E568D

c.1704G>T

1 paper

NM_005030.6

p.R560H

c.1679G>A

1 paper

NM_005030.6

p.R560C

c.1678C>T