Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.E575K

c.1723G>A

Surrounding Variants

1 paper

NM_005030.6

p.C573F

c.1718G>T

1 paper

NM_005030.6

p.A577V

c.1730C>T

1 paper

NM_005030.6

p.R579W

c.1735C>T

2 papers

NM_005030.6

p.G571S

c.1711G>A

2 papers

NM_005030.6

p.R579Q

c.1736G>A

1 paper

NM_005030.6

p.L580F

c.1738C>T

3 papers

NM_005030.6

p.R581C

c.1741C>T

1 paper

NM_005030.6

p.R581H

c.1742G>A

1 paper

NM_005030.6

p.E568D

c.1704G>C

1 paper

NM_005030.6

p.E568D

c.1704G>T

1 paper

NM_005030.6

p.E568A

c.1703A>C

1 paper

NM_005030.6

p.E568*

c.1702G>T