Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.S603Y

c.1808C>A

Surrounding Variants

1 paper

NM_005030.6

p.K601N

c.1803G>C

1 paper

NM_005030.6

p.K601N

c.1803G>T

1 paper

NM_005030.6

p.K601R

c.1802A>G

1 paper

NM_005030.6

p.K601Q

c.1801A>C

1 paper

NM_005030.6

p.L600F

c.1798C>T

1 paper

NM_005030.6

p.R599H

c.1796G>A

2 papers

NM_005030.6

p.R599C

c.1795C>T

1 paper

NM_005030.6

p.N598Y

c.1792A>T

1 paper

NM_005030.6

p.A596_S597delins

c.1788_1790delinsTGC

1 paper

NM_005030.6

p.A596V

c.1787C>T

1 paper

NM_005030.6

p.A596T

c.1786G>A

1 paper

NM_005030.6

p.S595*

c.1784C>A