Varaico: Literature-Extracted Genetic Variants

PLK4

171 papers

RefSeq Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centrio...

Pfam Domains

Pkinaseaa 12–265UCSCProtein kinase domain

Plk4_PB1aa 591–697UCSCPolo-like Kinase 4 Polo Box 1

Plk4_PB2aa 699–807UCSCPolo-like Kinase 4 Polo Box 2

Gene Aliases

HGNC Name

polo like kinase 4

HGNC Previous Symbol

STK18

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014264.5

p.M1insFs

c.1_2insTT

Surrounding Variants

1 paper

NM_014264.5

p.M1Fs

c.1delinsGAGFs

1 paper

NM_014264.5

p.M1I

c.3G>C

2 papers

NM_014264.5

p.A2T

c.4G>A

1 paper

NM_014264.5

p.A2G

c.5C>G

5 papers

NM_014264.5

p.G6E

c.17G>A

1 paper

NM_014264.5

p.E10A

c.29A>C

1 paper

NM_014264.5

p.E10_D11insFs

c.30_31ins31

3 papers

NM_014264.5

p.E10_D11Splc

c.31-3A>G

4 papers

NM_014264.5

p.D11fs

c.31_32fs

1 paper

NM_014264.5

p.F12C

c.35T>G

1 paper

NM_014264.5

p.N16S

c.47A>G

1 paper

NM_014264.5

p.L17M

c.49C>A