Varaico: Literature-Extracted Genetic Variants

PLK4

171 papers

RefSeq Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centrio...

Pfam Domains

Pkinaseaa 12–265UCSCProtein kinase domain

Plk4_PB1aa 591–697UCSCPolo-like Kinase 4 Polo Box 1

Plk4_PB2aa 699–807UCSCPolo-like Kinase 4 Polo Box 2

Gene Aliases

HGNC Name

polo like kinase 4

HGNC Previous Symbol

STK18

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_014264.5

p.L67_S71delFs

c.201_213del13

Surrounding Variants

3 papers

NM_014264.5

p.K68fs

c.202_203fs

1 paper

NM_014264.5

p.K68N

c.204A>C

1 paper

NM_014264.5

p.K68N

c.204A>T

1 paper

NM_014264.5

p.P70P

c.210T>A

1 paper

NM_014264.5

p.K62K

c.186A>G

2 papers

NM_014264.5

p.S71F

c.212C>T

1 paper

NM_014264.5

p.N59T

c.176A>C

1 paper

NM_014264.5

p.K46R

c.137A>G

1 paper

NM_014264.5

p.K46Q

c.136A>C

1 paper

NM_014264.5

p.K45R

c.134A>G

1 paper

NM_014264.5

p.K45Q

c.133A>C

1 paper

NM_014264.5

p.I43T

c.128T>C