Varaico: Literature-Extracted Genetic Variants

PLK4

171 papers

RefSeq Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centrio...

Pfam Domains

Pkinaseaa 12–265UCSCProtein kinase domain

Plk4_PB1aa 591–697UCSCPolo-like Kinase 4 Polo Box 1

Plk4_PB2aa 699–807UCSCPolo-like Kinase 4 Polo Box 2

Gene Aliases

HGNC Name

polo like kinase 4

HGNC Previous Symbol

STK18

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014264.5

p.S196T

c.586T>A

Surrounding Variants

1 paper

NM_014264.5

p.L190P

c.569T>C

1 paper

NM_014264.5

p.R185*

c.553C>T

1 paper

NM_014264.5

p.F211delFs

c.633delC

1 paper

NM_014264.5

p.D212N

c.634G>A

1 paper

NM_014264.5

p.D214insFs

c.642dupC

1 paper

NM_014264.5

p.Y177F

c.530A>T

1 paper

NM_014264.5

p.V216D

c.647T>A

1 paper

NM_014264.5

p.T174N

c.521C>A

1 paper

NM_014264.5

p.C172F

c.515G>T

1 paper

NM_014264.5

p.K162R

c.485A>G

5 papers

NM_014264.5

p.S232T

c.694T>A

1 paper

NM_014264.5

p.S232A

c.694T>G