Varaico: Literature-Extracted Genetic Variants

PLK4

171 papers

RefSeq Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centrio...

Pfam Domains

Pkinaseaa 12–265UCSCProtein kinase domain

Plk4_PB1aa 591–697UCSCPolo-like Kinase 4 Polo Box 1

Plk4_PB2aa 699–807UCSCPolo-like Kinase 4 Polo Box 2

Gene Aliases

HGNC Name

polo like kinase 4

HGNC Previous Symbol

STK18

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014264.5

p.Q316*

c.946C>T

Surrounding Variants

1 paper

NM_014264.5

p.G315C

c.943G>T

2 papers

NM_014264.5

p.P317L

c.950C>T

1 paper

NM_014264.5

p.S301R

c.903T>A

1 paper

NM_014264.5

p.S335A

c.1003T>G

3 papers

NM_014264.5

p.I294S

c.881T>G

1 paper

NM_014264.5

p.D339H

c.1015G>C

1 paper

NM_014264.5

p.I290I

c.870T>A

2 papers

NM_014264.5

p.T289A

c.865A>G

1 paper

NM_014264.5

p.H287R

c.860A>G

1 paper

NM_014264.5

p.T345A

c.1033A>G

1 paper

NM_014264.5

p.D281N

c.841G>A

1 paper

NM_014264.5

p.E351*

c.1051G>T