Varaico: Literature-Extracted Genetic Variants

PLK4

171 papers

RefSeq Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centrio...

Pfam Domains

Pkinaseaa 12–265UCSCProtein kinase domain

Plk4_PB1aa 591–697UCSCPolo-like Kinase 4 Polo Box 1

Plk4_PB2aa 699–807UCSCPolo-like Kinase 4 Polo Box 2

Gene Aliases

HGNC Name

polo like kinase 4

HGNC Previous Symbol

STK18

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014264.5

p.R359I

c.1076G>T

Surrounding Variants

1 paper

NM_014264.5

p.E351*

c.1051G>T

1 paper

NM_014264.5

p.S370A

c.1108T>G

2 papers

NM_014264.5

p.R371*

c.1111C>T

1 paper

NM_014264.5

p.T345A

c.1033A>G

1 paper

NM_014264.5

p.R374H

c.1121G>A

1 paper

NM_014264.5

p.R375_A376delFs

c.1125_1126delAG

1 paper

NM_014264.5

p.A376T

c.1126G>A

1 paper

NM_014264.5

p.D339H

c.1015G>C

1 paper

NM_014264.5

p.D380H

c.1138G>C

1 paper

NM_014264.5

p.D380Y

c.1138G>T

1 paper

NM_014264.5

p.R381K

c.1142G>A

1 paper

NM_014264.5

p.S335A

c.1003T>G